Assessment of the efficacy of treatment of patients with sickle cell disease with memantine (phase IIa-b trial|MemSID) using novel analytical techniques

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18525.1 PFLS-LS
• Titre du projet anglais: Assessment of the efficacy of treatment of patients with sickle cell disease with memantine (phase IIa-b trial|MemSID) using novel analytical techniques

Description succincte (Allemand)

Effizienzbestimmung der Behandlung von Sichelzellanämiepatienten mit dem Wirkstoff|Memantin (Phase IIa-b trial MemSID) mittels neueartiger Analysemethoden

Description succincte (Anglais)

Assessment of the efficacy of treatment of patients with sickle cell disease with memantine (phase IIa-b trial|MemSID) using novel analytical techniques

Résumé des résultats (Abstract) (Allemand)

Memantine, the NMDA receptor anatagonist is for the first time applied for treatment of patients with sickle cell|disease. The existing clinical lab test are insufficient to assess the effect of the drug on properties of the|circulating red cells. We suggest a battery of tests to evaluate red cell adherence, deformability, redox state,|calcium levels, volume and ion content using apporaches including novel microfluidic devices produced by our|industrial partners.

Résumé des résultats (Abstract) (Anglais)

Memantine, the NMDA receptor anatagonist is for the first time applied for treatment of patients with sickle cell|disease. The existing clinical lab test are insufficient to assess the effect of the drug on properties of the|circulating red cells. We suggest a battery of tests to evaluate red cell adherence, deformability, redox state,|calcium levels, volume and ion content using apporaches including novel microfluidic devices produced by our|industrial partners.