Adenosine A2A receptor positive allosteric modulators (PAM) as a novel broadly applicable oral anti-inflammatory therapy

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18283.1 PFLS-LS
• Titre du projet anglais: Adenosine A2A receptor positive allosteric modulators (PAM) as a novel broadly applicable oral anti-inflammatory therapy

Description succincte (Allemand)

Adenosine A2A receptor positive allosteric modulators (PAM) as a novel broadly applicable oral anti-inflammatory therapy

Description succincte (Anglais)

Adenosine A2A receptor positive allosteric modulators (PAM) as a novel broadly applicable oral anti-inflammatory therapy

Résumé des résultats (Abstract) (Allemand)

||||||To discover first-in-class selective small molecule A2AR PAM as a novel oral anti-inflammatory therapy. Because it preserves the natural spatio-temporal control over A2AR engagement, an A2AR PAM would avoid side effects relating to systemic triggering of A2AR and present distinct advantages over straight agonists by selectively enhancing the well-validated anti-inflammatory effects of high adenosine concentration only within inflamed tissues|||||||

Résumé des résultats (Abstract) (Anglais)