Adenosine A2A receptor positive allosteric modulators (PAM) as a novel broadly applicable oral anti-inflammatory therapy

• Research unit: INNOSUISSE
• Project number: 18283.1 PFLS-LS

Short description (German)

Adenosine A2A receptor positive allosteric modulators (PAM) as a novel broadly applicable oral anti-inflammatory therapy

Short description (English)

Adenosine A2A receptor positive allosteric modulators (PAM) as a novel broadly applicable oral anti-inflammatory therapy

Abstract (German)

||||||To discover first-in-class selective small molecule A2AR PAM as a novel oral anti-inflammatory therapy. Because it preserves the natural spatio-temporal control over A2AR engagement, an A2AR PAM would avoid side effects relating to systemic triggering of A2AR and present distinct advantages over straight agonists by selectively enhancing the well-validated anti-inflammatory effects of high adenosine concentration only within inflamed tissues|||||||

Abstract (English)