Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5

• Forschungsstelle: INNOSUISSE
• Projektnummer: 17635.1 PFLS-LS
• Projekttitel Englisch: Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5

Kurzbeschreibung (Deutsch)

Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5

Kurzbeschreibung (Englisch)

Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5

Abstract (Deutsch)

Clinical testing of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multivalent vaccine formulation. This CTI project should support design, optimisation and final preclinical profiling of additional mimotopes derived from key vaccine conserved antigens for protection against different strains in an innovative P. falciparum infection mouse model.

Abstract (Englisch)

Clinical testing of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multivalent vaccine formulation. This CTI project should support design, optimisation and final preclinical profiling of additional mimotopes derived from key vaccine conserved antigens for protection against different strains in an innovative P. falciparum infection mouse model.