Development of novel antibiotics with additional host-protective anti-inflammatory properties against life threatening infections caused by MDR Gram-negative ESKAPE pathogens

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18146.1 PFLS-LS
• Titre du projet anglais: Development of novel antibiotics with additional host-protective anti-inflammatory properties against life threatening infections caused by MDR Gram-negative ESKAPE pathogens

Description succincte (Allemand)

Development of novel antibiotics with additional host-protective anti-inflammatory properties against life threatening infections caused by MDR Gram-negative ESKAPE pathogens

Description succincte (Anglais)

Development of novel antibiotics with additional host-protective anti-inflammatory properties against life threatening infections caused by MDR Gram-negative ESKAPE pathogens

Résumé des résultats (Abstract) (Allemand)

In earlier work, POL7080 was discovered; an antibiotic targeting Pseudomonas aeruginosa with a novel mode-of-action, which is currently in Phase II clinical trials. In this project, a new series of peptidomimetics with a broader spectrum of antibacterial activity against multi-drug resistant (MDR) and colistin-resistant Gram-negative ESKAPE pathogens will be studied, possessing also potential host-protective anti-inflammatory activity.

Résumé des résultats (Abstract) (Anglais)

In earlier work, POL7080 was discovered; an antibiotic targeting Pseudomonas aeruginosa with a novel mode-of-action, which is currently in Phase II clinical trials. In this project, a new series of peptidomimetics with a broader spectrum of antibacterial activity against multi-drug resistant (MDR) and colistin-resistant Gram-negative ESKAPE pathogens will be studied, possessing also potential host-protective anti-inflammatory activity.