Development of novel antibiotics with additional host-protective anti-inflammatory properties against life threatening infections caused by MDR Gram-negative ESKAPE pathogens

• Research unit: INNOSUISSE
• Project number: 18146.1 PFLS-LS

Short description (German)

Development of novel antibiotics with additional host-protective anti-inflammatory properties against life threatening infections caused by MDR Gram-negative ESKAPE pathogens

Short description (English)

Development of novel antibiotics with additional host-protective anti-inflammatory properties against life threatening infections caused by MDR Gram-negative ESKAPE pathogens

Abstract (German)

In earlier work, POL7080 was discovered; an antibiotic targeting Pseudomonas aeruginosa with a novel mode-of-action, which is currently in Phase II clinical trials. In this project, a new series of peptidomimetics with a broader spectrum of antibacterial activity against multi-drug resistant (MDR) and colistin-resistant Gram-negative ESKAPE pathogens will be studied, possessing also potential host-protective anti-inflammatory activity.

Abstract (English)

In earlier work, POL7080 was discovered; an antibiotic targeting Pseudomonas aeruginosa with a novel mode-of-action, which is currently in Phase II clinical trials. In this project, a new series of peptidomimetics with a broader spectrum of antibacterial activity against multi-drug resistant (MDR) and colistin-resistant Gram-negative ESKAPE pathogens will be studied, possessing also potential host-protective anti-inflammatory activity.