Profiling of new oxytocin receptor agonists for the treatment of anxiety and autism spectrum disorders through a new microdrive-mounted optrode allowing combined electrophysiological and fMRI analyses.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18546.1 PFLS-LS
• Titre du projet anglais: Profiling of new oxytocin receptor agonists for the treatment of anxiety and autism spectrum disorders through a new microdrive-mounted optrode allowing combined electrophysiological and fMRI analyses.

Description succincte (Allemand)

Profiling of new oxytocin receptor agonists for the treatment of anxiety and autism spectrum disorders through a new microdrive-mounted optrode allowing combined electrophysiological and fMRI analyses.

Description succincte (Anglais)

Profiling of new oxytocin receptor agonists for the treatment of anxiety and autism spectrum disorders through a new microdrive-mounted optrode allowing combined electrophysiological and fMRI analyses.

Résumé des résultats (Abstract) (Allemand)

To profile newly developed oxytocin receptor agonists for anxiety and autism spectrum disorders by comparing their actions with those of endogenous oxytocin signaling in relevant brain circuits, we will construct and implement a fMRI compatible microdrive-mounted optrode that allows measurements of effects of optogenetically stimulated release of endogenous oxytocin using simultaneous fMRI scannings and electrophysiological recordings of single unit neuronal activity.

Résumé des résultats (Abstract) (Anglais)

To profile newly developed oxytocin receptor agonists for anxiety and autism spectrum disorders by comparing their actions with those of endogenous oxytocin signaling in relevant brain circuits, we will construct and implement a fMRI compatible microdrive-mounted optrode that allows measurements of effects of optogenetically stimulated release of endogenous oxytocin using simultaneous fMRI scannings and electrophysiological recordings of single unit neuronal activity.