Profiling of new oxytocin receptor agonists for the treatment of anxiety and autism spectrum disorders through a new microdrive-mounted optrode allowing combined electrophysiological and fMRI analyses.

• Research unit: INNOSUISSE
• Project number: 18546.1 PFLS-LS

Short description (German)

Profiling of new oxytocin receptor agonists for the treatment of anxiety and autism spectrum disorders through a new microdrive-mounted optrode allowing combined electrophysiological and fMRI analyses.

Short description (English)

Profiling of new oxytocin receptor agonists for the treatment of anxiety and autism spectrum disorders through a new microdrive-mounted optrode allowing combined electrophysiological and fMRI analyses.

Abstract (German)

To profile newly developed oxytocin receptor agonists for anxiety and autism spectrum disorders by comparing their actions with those of endogenous oxytocin signaling in relevant brain circuits, we will construct and implement a fMRI compatible microdrive-mounted optrode that allows measurements of effects of optogenetically stimulated release of endogenous oxytocin using simultaneous fMRI scannings and electrophysiological recordings of single unit neuronal activity.

Abstract (English)

To profile newly developed oxytocin receptor agonists for anxiety and autism spectrum disorders by comparing their actions with those of endogenous oxytocin signaling in relevant brain circuits, we will construct and implement a fMRI compatible microdrive-mounted optrode that allows measurements of effects of optogenetically stimulated release of endogenous oxytocin using simultaneous fMRI scannings and electrophysiological recordings of single unit neuronal activity.