Structure-based drug discovery with thermostabilized G protein-coupled receptors (GPCR)

• Research unit: INNOSUISSE
• Project number: 18022.1 PFLS-LS

Short description (German)

Structure-based drug discovery with thermostabilized G protein-coupled receptors (GPCR)

Short description (English)

Structure-based drug discovery with thermostabilized G protein-coupled receptors (GPCR)

Abstract (German)

G protein-coupled receptors (GPCRs) are the single largest class of validated drug targets. Current|approaches in GPCR drug development led to significant failure rates and no successful novel chemical|entities (NCEs) to multiple high-value GPCR targets. G7 Therapeutics in collaboration with the University of|Zurich will apply its CHESS technology to identify and visualize the interaction of NCEs with GPCR targets of|clinical importance in order to create better medication.

Abstract (English)

G protein-coupled receptors (GPCRs) are the single largest class of validated drug targets. Current|approaches in GPCR drug development led to significant failure rates and no successful novel chemical|entities (NCEs) to multiple high-value GPCR targets. G7 Therapeutics in collaboration with the University of|Zurich will apply its CHESS technology to identify and visualize the interaction of NCEs with GPCR targets of|clinical importance in order to create better medication.