Structure-based drug discovery with thermostabilized G protein-coupled receptors (GPCR)

• Forschungsstelle: INNOSUISSE
• Projektnummer: 18022.1 PFLS-LS
• Projekttitel Englisch: Structure-based drug discovery with thermostabilized G protein-coupled receptors (GPCR)

Kurzbeschreibung (Deutsch)

Structure-based drug discovery with thermostabilized G protein-coupled receptors (GPCR)

Kurzbeschreibung (Englisch)

Structure-based drug discovery with thermostabilized G protein-coupled receptors (GPCR)

Abstract (Deutsch)

G protein-coupled receptors (GPCRs) are the single largest class of validated drug targets. Current|approaches in GPCR drug development led to significant failure rates and no successful novel chemical|entities (NCEs) to multiple high-value GPCR targets. G7 Therapeutics in collaboration with the University of|Zurich will apply its CHESS technology to identify and visualize the interaction of NCEs with GPCR targets of|clinical importance in order to create better medication.

Abstract (Englisch)

G protein-coupled receptors (GPCRs) are the single largest class of validated drug targets. Current|approaches in GPCR drug development led to significant failure rates and no successful novel chemical|entities (NCEs) to multiple high-value GPCR targets. G7 Therapeutics in collaboration with the University of|Zurich will apply its CHESS technology to identify and visualize the interaction of NCEs with GPCR targets of|clinical importance in order to create better medication.