Validation of small compound hits against a novel therapeutic target in colorectal cancer

• Unité de recherche: INNOSUISSE
• Numéro de projet: 17637.1 PFLS-LS
• Titre du projet anglais: Validation of small compound hits against a novel therapeutic target in colorectal cancer

Description succincte (Allemand)

Validation of small compound hits against a novel therapeutic target in colorectal cancer

Description succincte (Anglais)

Validation of small compound hits against a novel therapeutic target in colorectal cancer

Résumé des résultats (Abstract) (Allemand)

We have identified a protein-protein interaction as a novel therapeutic target in colon cancer and screened approx. 380'000 compounds from different libraries of chemically diverse, drug-like molecules. 39 hits (IC50 1-20ìM) were confirmed in two independent assays. This feasibility study is to assess the binding properties of these compounds by surface plasmon resonance and/or isothermal titration calorimetry, as a basis to raise seed-funding for hit-to-lead optimization.

Résumé des résultats (Abstract) (Anglais)

We have identified a protein-protein interaction as a novel therapeutic target in colon cancer and screened approx. 380'000 compounds from different libraries of chemically diverse, drug-like molecules. 39 hits (IC50 1-20ìM) were confirmed in two independent assays. This feasibility study is to assess the binding properties of these compounds by surface plasmon resonance and/or isothermal titration calorimetry, as a basis to raise seed-funding for hit-to-lead optimization.