Validation of small compound hits against a novel therapeutic target in colorectal cancer

• Forschungsstelle: INNOSUISSE
• Projektnummer: 17637.1 PFLS-LS
• Projekttitel Englisch: Validation of small compound hits against a novel therapeutic target in colorectal cancer

Kurzbeschreibung (Deutsch)

Validation of small compound hits against a novel therapeutic target in colorectal cancer

Kurzbeschreibung (Englisch)

Validation of small compound hits against a novel therapeutic target in colorectal cancer

Abstract (Deutsch)

We have identified a protein-protein interaction as a novel therapeutic target in colon cancer and screened approx. 380'000 compounds from different libraries of chemically diverse, drug-like molecules. 39 hits (IC50 1-20ìM) were confirmed in two independent assays. This feasibility study is to assess the binding properties of these compounds by surface plasmon resonance and/or isothermal titration calorimetry, as a basis to raise seed-funding for hit-to-lead optimization.

Abstract (Englisch)

We have identified a protein-protein interaction as a novel therapeutic target in colon cancer and screened approx. 380'000 compounds from different libraries of chemically diverse, drug-like molecules. 39 hits (IC50 1-20ìM) were confirmed in two independent assays. This feasibility study is to assess the binding properties of these compounds by surface plasmon resonance and/or isothermal titration calorimetry, as a basis to raise seed-funding for hit-to-lead optimization.