Chemical warheads targeting cancer and inflammatory disorders: MIP: PIQUR Therapeutics AG

• Research unit: INNOSUISSE
• Project number: 17241.1 PFLS-LS

Short description (German)

Chemical warheads targeting cancer and inflammatory disorders

Short description (English)

Chemical warheads targeting cancer and inflammatory disorders: MIP: PIQUR Therapeutics AG

Abstract (German)

PIQUR and UniBas propose to co-develop a novel strategy to produce covalent inhibitors targeting PI3K/mTOR in cancer and inflammation. The project aims to equip PIQUR with currently unexplored technologyies in the PI3K/mTOR field, and allows UniBas to to study selective PI3K/mTOR-dependent disease mechanisms by Chemical Genetics. Central is entry into uncharted IP space, enlargement of the PIQUR portfolio, the implementation of a proprietary kinase targeting platform, and a highly selective validation of PI3K isoforms as pharmaceutical drug targets.

Abstract (English)

PIQUR and UniBas propose to co-develop a novel strategy to produce covalent inhibitors targeting PI3K/mTOR in cancer and inflammation. The project aims to equip PIQUR with currently unexplored technologyies in the PI3K/mTOR field, and allows UniBas to to study selective PI3K/mTOR-dependent disease mechanisms by Chemical Genetics. Central is entry into uncharted IP space, enlargement of the PIQUR portfolio, the implementation of a proprietary kinase targeting platform, and a highly selective validation of PI3K isoforms as pharmaceutical drug targets.