Drugs Activated When Needed (DAWN)

• Research unit: INNOSUISSE
• Project number: 17072.1 PFLS-LS

Short description (German)

Drugs Activated When Needed (DAWN)

Short description (English)

Drugs Activated When Needed (DAWN)

Abstract (German)

The use of delivery vehicles is at the basis of better tolerable and more efficacious novel classes of targeted drugs [termed Antibody- (ADC-)or Small molecule-(SMDC-)Drug Conjugates). Until now the development of ADC and SMDC relies on target cells internalization, which is difficult to measure and exploit. Here we will develop a novel and superior class of ADC and SMDC which will not require internalization of delivery vehicles and will liberate the toxic payload on demand.

Abstract (English)