Inhibitory therapeutics of Death Receptor 3 (DR3) for treatment of autoimmune disorders

• Unité de recherche: INNOSUISSE
• Numéro de projet: 16447.2 PFLS-LS
• Titre du projet anglais: Inhibitory therapeutics of Death Receptor 3 (DR3) for treatment of autoimmune disorders

Description succincte (Allemand)

Inhibitory therapeutics of Death Receptor 3 (DR3) for treatment of autoimmune disorders

Description succincte (Anglais)

Inhibitory therapeutics of Death Receptor 3 (DR3) for treatment of autoimmune disorders

Résumé des résultats (Abstract) (Allemand)

The project is a multi-faceted approach towards identification of a novel treatment of autoimmune disorders such as IBD and RA. AIDD, in collaboration with UNIGE, will identify small molecule inhibitors of Death Receptor 3 (DR3) using an innovative combined biosensor - fragment screening - nanobody screening approach. The output of this project will be a series of first family hit DR3 inhibitors demonstrating promise for further optimization towards drug candidates.

Résumé des résultats (Abstract) (Anglais)