Identification and characterization of specific venom-derived peptides inhibiting the Tumour Necrosis Factor receptor 1: development of novel anti-inflammatory drug candidates

• Unité de recherche: INNOSUISSE
• Numéro de projet: 16640.1 PFLS-LS
• Titre du projet anglais: Identification and characterization of specific venom-derived peptides inhibiting the Tumour Necrosis Factor receptor 1: development of novel anti-inflammatory drug candidates

Description succincte (Allemand)

Identification and characterization of specific venom-derived peptides inhibiting the Tumour Necrosis Factor receptor 1: development of novel anti-inflammatory drug candidates

Description succincte (Anglais)

Identification and characterization of specific venom-derived peptides inhibiting the Tumour Necrosis Factor receptor 1: development of novel anti-inflammatory drug candidates

Résumé des résultats (Abstract) (Allemand)

Our objective is the discovery of venom peptides selectively inhibiting the binding of Tumor Necrosis Factor (TNF) to TNF receptor 1 (TNFR1) as anti-inflammatory drug candidates. Active venom extracts identified after screening of a library using a novel assay will be submitted to deconvolution. After purification, structural elucidation and synthesis of the best candidates, the most promising molecules will be characterized and their druggability potential will be assessed.

Résumé des résultats (Abstract) (Anglais)

Our objective is the discovery of venom peptides selectively inhibiting the binding of Tumor Necrosis Factor (TNF) to TNF receptor 1 (TNFR1) as anti-inflammatory drug candidates. Active venom extracts identified after screening of a library using a novel assay will be submitted to deconvolution. After purification, structural elucidation and synthesis of the best candidates, the most promising molecules will be characterized and their druggability potential will be assessed.