Identification and characterization of specific venom-derived peptides inhibiting the Tumour Necrosis Factor receptor 1: development of novel anti-inflammatory drug candidates

• Research unit: INNOSUISSE
• Project number: 16640.1 PFLS-LS

Short description (German)

Identification and characterization of specific venom-derived peptides inhibiting the Tumour Necrosis Factor receptor 1: development of novel anti-inflammatory drug candidates

Short description (English)

Identification and characterization of specific venom-derived peptides inhibiting the Tumour Necrosis Factor receptor 1: development of novel anti-inflammatory drug candidates

Abstract (German)

Our objective is the discovery of venom peptides selectively inhibiting the binding of Tumor Necrosis Factor (TNF) to TNF receptor 1 (TNFR1) as anti-inflammatory drug candidates. Active venom extracts identified after screening of a library using a novel assay will be submitted to deconvolution. After purification, structural elucidation and synthesis of the best candidates, the most promising molecules will be characterized and their druggability potential will be assessed.

Abstract (English)

Our objective is the discovery of venom peptides selectively inhibiting the binding of Tumor Necrosis Factor (TNF) to TNF receptor 1 (TNFR1) as anti-inflammatory drug candidates. Active venom extracts identified after screening of a library using a novel assay will be submitted to deconvolution. After purification, structural elucidation and synthesis of the best candidates, the most promising molecules will be characterized and their druggability potential will be assessed.