Establishment of a platform for the study of liver disease (fibrosis) in vitro

• Research unit: INNOSUISSE
• Project number: 16856.1 PFLS-LS

Short description (German)

Establishment of a platform for the study of liver disease (fibrosis) in vitro

Short description (English)

Establishment of a platform for the study of liver disease (fibrosis) in vitro

Abstract (German)

We aim at developing a 3D microtissue culture to study liver fibrosis and cirrhosis. This in vitro system will|contain functional hepatocytes, Kupffer and stellate cells. We will evaluate primary human liver cells with|these key cell types, as well as available cell lines of human origin. To address translational aspects, we|will also establish a rodent-based system. Both systems will be applicable for toxicity studies, disease|progression and responses to pharmacological intervention. They will be made commecially available as|an off-the-shelf product or as a fee-for-service assay.

Abstract (English)

We aim at developing a 3D microtissue culture to study liver fibrosis and cirrhosis. This in vitro system will|contain functional hepatocytes, Kupffer and stellate cells. We will evaluate primary human liver cells with|these key cell types, as well as available cell lines of human origin. To address translational aspects, we|will also establish a rodent-based system. Both systems will be applicable for toxicity studies, disease|progression and responses to pharmacological intervention. They will be made commecially available as|an off-the-shelf product or as a fee-for-service assay.