Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases

• Research unit: INNOSUISSE
• Project number: 16018.2 PFLS-LS

Short description (German)

Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases

Short description (English)

Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases

Abstract (German)

A novel mechanism of action for the sustainable therapy of human chronic inflammatory diseases, acting|through targeted lysis of disease-driving cell, shall be investigated here. A lead molecule active in human|and non-human primates has been identified and will be developed to enable clinical testing. To support|the preclinical development a bispecific surrogate antibody fragment active in mice will be engineered and|tested in relevant mouse models for chronic inflammatory diseases to study efficacy as well as certain|safety relevant parameters.

Abstract (English)

A novel mechanism of action for the sustainable therapy of human chronic inflammatory diseases, acting|through targeted lysis of disease-driving cell, shall be investigated here. A lead molecule active in human|and non-human primates has been identified and will be developed to enable clinical testing. To support|the preclinical development a bispecific surrogate antibody fragment active in mice will be engineered and|tested in relevant mouse models for chronic inflammatory diseases to study efficacy as well as certain|safety relevant parameters.