Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases

Forschungsstelle

INNOSUISSE

Projektnummer

16018.2 PFLS-LS

Projekttitel

Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases

Projekttitel Englisch

Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases

Texte zu diesem Projekt

	Deutsch	Französisch	Italienisch	Englisch
Kurzbeschreibung		-	-
Abstract		-	-

Kategorie	Text
Kurzbeschreibung (Deutsch)	Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases
Kurzbeschreibung (Englisch)	Targeting of the IL-23 Receptor to eliminate auto-reactive lymphocytes in chronic inflammatory diseases
Abstract (Deutsch)	A novel mechanism of action for the sustainable therapy of human chronic inflammatory diseases, acting\|through targeted lysis of disease-driving cell, shall be investigated here. A lead molecule active in human\|and non-human primates has been identified and will be developed to enable clinical testing. To support\|the preclinical development a bispecific surrogate antibody fragment active in mice will be engineered and\|tested in relevant mouse models for chronic inflammatory diseases to study efficacy as well as certain\|safety relevant parameters.
Abstract (Englisch)	A novel mechanism of action for the sustainable therapy of human chronic inflammatory diseases, acting\|through targeted lysis of disease-driving cell, shall be investigated here. A lead molecule active in human\|and non-human primates has been identified and will be developed to enable clinical testing. To support\|the preclinical development a bispecific surrogate antibody fragment active in mice will be engineered and\|tested in relevant mouse models for chronic inflammatory diseases to study efficacy as well as certain\|safety relevant parameters.