Engineering of smart collagen-based tubular matrices for regenerative medicine

• Forschungsstelle: INNOSUISSE
• Projektnummer: 16627.1 PFLS-LS
• Projekttitel Englisch: Engineering of smart collagen-based tubular matrices for regenerative medicine

Kurzbeschreibung (Deutsch)

Engineering of smart collagen-based tubular matrices for regenerative medicine

Kurzbeschreibung (Englisch)

Engineering of smart collagen-based tubular matrices for regenerative medicine

Abstract (Deutsch)

The aim of this project is to produce off-the-shelf tubular native and modified collagen implants for urinary tract and vascular tissue engineering. The bioactivity of the matrices will also be further enhanced by incorporation of cell-engineered human extracellular matrix proteins deposited by the respective cell type, followed by decellularization. This cell-engineering will be performed in a specially developed flow-bioreactor. Further, smart matrices are produced by combining collagen and fibrin, allowing covalent binding of specific growth factors, promoting in vivo cell-ingrowth. The respective matrices are packed and sterilised, to then be available as a commercial product.

Abstract (Englisch)

The aim of this project is to produce off-the-shelf tubular native and modified collagen implants for urinary tract and vascular tissue engineering. The bioactivity of the matrices will also be further enhanced by incorporation of cell-engineered human extracellular matrix proteins deposited by the respective cell type, followed by decellularization. This cell-engineering will be performed in a specially developed flow-bioreactor. Further, smart matrices are produced by combining collagen and fibrin, allowing covalent binding of specific growth factors, promoting in vivo cell-ingrowth. The respective matrices are packed and sterilised, to then be available as a commercial product.