Establishment of a fully synthetic, mirror-image biological system - Texts

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Research unit

INNOSUISSE

Project number

16101.1 PFLS-LS

Project title

Establishment of a fully synthetic, mirror-image biological system

Texts for this project

	German	French	Italian	English
Short description		-	-
Abstract		-	-

Inserted texts

Category	Text
Short description (German)	Establishment of a fully synthetic, mirror-image biological system
Short description (English)	Establishment of a fully synthetic, mirror-image biological system
Abstract (German)	Our goal is to create a mirror-image synthetic biology, independent of nature. Starting from L-nucleotides and\|D-amino acids, we will use chemical synthesis to establish a functioning mirror-image biological system from\|artificial components. There are immediate practical outcomes: D-DARPins will not be substrates of natural proteases, permitting oral application, and they may fundamentally overcome immunogenicity, the most\|principal limitation of therapeutic proteins.
Abstract (English)	Our goal is to create a mirror-image synthetic biology, independent of nature. Starting from L-nucleotides and\|D-amino acids, we will use chemical synthesis to establish a functioning mirror-image biological system from\|artificial components. There are immediate practical outcomes: D-DARPins will not be substrates of natural proteases, permitting oral application, and they may fundamentally overcome immunogenicity, the most\|principal limitation of therapeutic proteins.