SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 16003.1 PFLS-LS
• Titre du projet anglais: SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Description succincte (Allemand)

SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Description succincte (Anglais)

SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Résumé des résultats (Abstract) (Allemand)

Neurotransmitter/ion transporters and G protein-coupled receptors are druggable targets, but are suffering from a very high compound attrition rate. Recently, biophysical assays and structure-based drug design have enabled to overcome this hurdle but their development is time-consuming. Now, we aim at improving this process using synthetic camelid single domain antibody fragments (SwissBodies). In a novel and fast procedure we generate tailored SwissBodies to accelerate the development of novel biophysical tools and reduce compound attrition rates.

Résumé des résultats (Abstract) (Anglais)

Neurotransmitter/ion transporters and G protein-coupled receptors are druggable targets, but are suffering from a very high compound attrition rate. Recently, biophysical assays and structure-based drug design have enabled to overcome this hurdle but their development is time-consuming. Now, we aim at improving this process using synthetic camelid single domain antibody fragments (SwissBodies). In a novel and fast procedure we generate tailored SwissBodies to accelerate the development of novel biophysical tools and reduce compound attrition rates.