SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

• Research unit: INNOSUISSE
• Project number: 16003.1 PFLS-LS

Short description (German)

SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Short description (English)

SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Abstract (German)

Neurotransmitter/ion transporters and G protein-coupled receptors are druggable targets, but are suffering from a very high compound attrition rate. Recently, biophysical assays and structure-based drug design have enabled to overcome this hurdle but their development is time-consuming. Now, we aim at improving this process using synthetic camelid single domain antibody fragments (SwissBodies). In a novel and fast procedure we generate tailored SwissBodies to accelerate the development of novel biophysical tools and reduce compound attrition rates.

Abstract (English)

Neurotransmitter/ion transporters and G protein-coupled receptors are druggable targets, but are suffering from a very high compound attrition rate. Recently, biophysical assays and structure-based drug design have enabled to overcome this hurdle but their development is time-consuming. Now, we aim at improving this process using synthetic camelid single domain antibody fragments (SwissBodies). In a novel and fast procedure we generate tailored SwissBodies to accelerate the development of novel biophysical tools and reduce compound attrition rates.