SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

• Forschungsstelle: INNOSUISSE
• Projektnummer: 16003.1 PFLS-LS
• Projekttitel Englisch: SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Kurzbeschreibung (Deutsch)

SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Kurzbeschreibung (Englisch)

SwissBody-enabled small molecule drug discovery for neurotransmitter/ion transporters and G protein-coupled receptors.

Abstract (Deutsch)

Neurotransmitter/ion transporters and G protein-coupled receptors are druggable targets, but are suffering from a very high compound attrition rate. Recently, biophysical assays and structure-based drug design have enabled to overcome this hurdle but their development is time-consuming. Now, we aim at improving this process using synthetic camelid single domain antibody fragments (SwissBodies). In a novel and fast procedure we generate tailored SwissBodies to accelerate the development of novel biophysical tools and reduce compound attrition rates.

Abstract (Englisch)

Neurotransmitter/ion transporters and G protein-coupled receptors are druggable targets, but are suffering from a very high compound attrition rate. Recently, biophysical assays and structure-based drug design have enabled to overcome this hurdle but their development is time-consuming. Now, we aim at improving this process using synthetic camelid single domain antibody fragments (SwissBodies). In a novel and fast procedure we generate tailored SwissBodies to accelerate the development of novel biophysical tools and reduce compound attrition rates.