Development of novel bacterial sortase enzymes for site-specific conjugation of payloads to|antibodies

• Research unit: INNOSUISSE
• Project number: 16312.1 PFLS-LS

Short description (German)

Development of novel bacterial sortase enzymes for site-specific conjugation of payloads to antibodies

Short description (English)

Development of novel bacterial sortase enzymes for site-specific conjugation of payloads to|antibodies

Abstract (German)

Antibody conjugates have recently been proven to be highly potent anti-tumour drugs, exceeding the efficacy of conventional antibodies. There is great commercial interest in|developing site-specific payload conjugation technologies. We have established sortaseenzyme|mediated site-specific toxin conjugation to mAbs with sortase A known in the prior art. We aim to develop novel, patentable sortase variants with improved and altered|specificities for extending the technology and IP base of the commercial partner.

Abstract (English)

Antibody conjugates have recently been proven to be highly potent anti-tumour drugs, exceeding the efficacy of conventional antibodies. There is great commercial interest in|developing site-specific payload conjugation technologies. We have established sortaseenzyme|mediated site-specific toxin conjugation to mAbs with sortase A known in the prior art. We aim to develop novel, patentable sortase variants with improved and altered|specificities for extending the technology and IP base of the commercial partner.