Development of functional therapeutic antibodies via next generation DNA sequencing and bioinformatic analysis of whole B cell antibody repertoires

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Research unit

INNOSUISSE

Project number

15460.1;9 PFLS-LS

Project title

Development of functional therapeutic antibodies via next generation DNA sequencing and bioinformatic analysis of whole B cell antibody repertoires

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Short description	-	-	-
Abstract	-	-	-

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Short description (English)	Development of functional therapeutic antibodies via next generation DNA sequencing and bioinformatic analysis of whole B cell antibody repertoires
Abstract (English)	This proposal aims at combining the expertise of Prof. Reddy's group in antibody discovery by next-generation DNA sequencing & bioinformatics with NBE-Therapeutics antibody discovery know-how, for a) the development of cancer-specific antibodies, b.) the development of optimized bioinformatic algorithms to generate 'super-humanized' antibodies, and c.) to develop a novel modular synthetic gene assembly process that enables rapid, cloning free construction of super-humanized antibodies.

Category

Text

Short description
(English)

Development of functional therapeutic antibodies via next generation DNA sequencing and bioinformatic analysis of whole B cell antibody repertoires

Abstract
(English)

This proposal aims at combining the expertise of Prof. Reddy's group in antibody discovery by next-generation DNA sequencing & bioinformatics with NBE-Therapeutics antibody discovery know-how, for a) the development of cancer-specific antibodies, b.) the development of optimized bioinformatic algorithms to generate 'super-humanized' antibodies, and c.) to develop a novel modular synthetic gene assembly process that enables rapid, cloning free construction of super-humanized antibodies.