HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory|Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

• Unité de recherche: INNOSUISSE
• Numéro de projet: 15235.1 PFLS-LS
• Titre du projet anglais: HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory|Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

Description succincte (Allemand)

HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

Description succincte (Anglais)

HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory|Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

Résumé des résultats (Abstract) (Allemand)

A new and highly innovative treatment will be realized by a novel and patentable small molecule|combinatorial drug candidate for the treatment of antibiotic resistance in multi-resistant, pathogenic|staphylococci. The consortium integrates a screening platform, biophysical characterization of small|molecules, medicinal chemistry, high-end characterization of mode of action and the in vivo mouse models,|to develop initial HIT compounds into preclinical candidates

Résumé des résultats (Abstract) (Anglais)

A new and highly innovative treatment will be realized by a novel and patentable small molecule|combinatorial drug candidate for the treatment of antibiotic resistance in multi-resistant, pathogenic|staphylococci. The consortium integrates a screening platform, biophysical characterization of small|molecules, medicinal chemistry, high-end characterization of mode of action and the in vivo mouse models,|to develop initial HIT compounds into preclinical candidates