HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

• Forschungsstelle: INNOSUISSE
• Projektnummer: 15235.1 PFLS-LS
• Projekttitel Englisch: HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory|Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

Kurzbeschreibung (Deutsch)

HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

Kurzbeschreibung (Englisch)

HIT to LEAD to Preclinical Candidate development of a Transcription Repressor Inhibitory|Compound (TRIC) that increase antibiotic susceptibility of multidrug resistant staphylococci

Abstract (Deutsch)

A new and highly innovative treatment will be realized by a novel and patentable small molecule|combinatorial drug candidate for the treatment of antibiotic resistance in multi-resistant, pathogenic|staphylococci. The consortium integrates a screening platform, biophysical characterization of small|molecules, medicinal chemistry, high-end characterization of mode of action and the in vivo mouse models,|to develop initial HIT compounds into preclinical candidates

Abstract (Englisch)

A new and highly innovative treatment will be realized by a novel and patentable small molecule|combinatorial drug candidate for the treatment of antibiotic resistance in multi-resistant, pathogenic|staphylococci. The consortium integrates a screening platform, biophysical characterization of small|molecules, medicinal chemistry, high-end characterization of mode of action and the in vivo mouse models,|to develop initial HIT compounds into preclinical candidates