Use of DNA-based Beacon Aptamers in pharmaceutical development

• Research unit: INNOSUISSE
• Project number: 14860.1;3 PFLS-LS

Short description (English)

Use of DNA-based Beacon Aptamers in pharmaceutical development

Short description (French)

Use of DNA-based Beacon Aptamers in pharmaceutical development

Abstract (English)

Chemical and biological analyses of Active Pharmaceutical Ingredients (API) play a key role during drug development. However, commonly used analytical systems either lack specificity or require costly and complex machineries. Beacon Aptamer coupled with Surface Plasmon Resonance (BA-SPR) provide high specificity in a simpler system. Our work will focus on two APIs from the company¿s pipeline to develop and evaluate an innovative way to analyse API during drug development.

Abstract (French)

Chemical and biological analyses of Active Pharmaceutical Ingredients (API) play a key role during drug development. However, commonly used analytical systems either lack specificity or require costly and complex machineries. Beacon Aptamer coupled with Surface Plasmon Resonance (BA-SPR) provide high specificity in a simpler system. Our work will focus on two APIs from the company¿s pipeline to develop and evaluate an innovative way to analyse API during drug development.