Erythrocyte-binding Uricase for Inducing Immunological Tolerance - Texts

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Research unit

INNOSUISSE

Project number

13766.3 PFLS-LS

Project title

Erythrocyte-binding Uricase for Inducing Immunological Tolerance

Texts for this project

	German	French	Italian	English
Short description		-	-
Abstract		-	-

Inserted texts

Category	Text
Short description (German)	Erythrocyte-binding Uricase for Inducing Immunological Tolerance
Short description (English)	Erythrocyte-binding Uricase for Inducing Immunological Tolerance
Abstract (German)	A protein engineering technology will be developed for induction of antigen-specific immunological tolerance,\|applicable for tolerance to protein drugs and to autoimmunity antigens. In this project, the technology will be\|developed in the context of reducing the unwanted immunogenicity reactions towards the therapeutic protein\|drug uricase (urate oxidase, Rasburicase), by engineering tolerogenic forms of uricase and thus enabling\|safe treatment of tumor lysis syndrome and gout.
Abstract (English)	A protein engineering technology will be developed for induction of antigen-specific immunological tolerance,\|applicable for tolerance to protein drugs and to autoimmunity antigens. In this project, the technology will be\|developed in the context of reducing the unwanted immunogenicity reactions towards the therapeutic protein\|drug uricase (urate oxidase, Rasburicase), by engineering tolerogenic forms of uricase and thus enabling\|safe treatment of tumor lysis syndrome and gout.