Establishment of a predictive model for chemical permeation across the human airway epithelium in vitro using MucilAirTM

• Research unit: INNOSUISSE
• Project number: 14000.1;6 PFLS-LS

Short description (English)

Establishment of a predictive model for chemical permeation across the human airway epithelium in vitro using MucilAirTM

Short description (French)

Establishment of a predictive model for chemical permeation across the human airway epithelium in vitro using MucilAirTM

Abstract (English)

To evaluate the effects of the chemicals on human health, it is necessary to know how the chemical interacts with and across the physical barriers such as airway epithelia. In this CTI project, we will evaluate the permeation of 40 chemicals using MucilAirTM, an in vitro cell model of the human airway epithelia made by Epithelix, which closely mimics the morphology and function of the human native tissues. The results will be compared to the in vivo data (animal and human). The final goal of this project is to establish a predictive model for pre-validation by ECVAM.

Abstract (French)

To evaluate the effects of the chemicals on human health, it is necessary to know how the chemical interacts with and across the physical barriers such as airway epithelia. In this CTI project, we will evaluate the permeation of 40 chemicals using MucilAirTM, an in vitro cell model of the human airway epithelia made by Epithelix, which closely mimics the morphology and function of the human native tissues. The results will be compared to the in vivo data (animal and human). The final goal of this project is to establish a predictive model for pre-validation by ECVAM.