Implantable photo-stimulation system for the treatment of Parkinson¿s disease

• Forschungsstelle: INNOSUISSE
• Projektnummer: 14660.1;13 PFLS-LS
• Projekttitel Englisch: Implantable photo-stimulation system for the treatment of Parkinson¿s disease

Kurzbeschreibung (Englisch)

Implantable photo-stimulation system for the treatment of Parkinson¿s disease

Kurzbeschreibung (Französisch)

Implantable photo-stimulation system for the treatment of Parkinson's disease

Abstract (Englisch)

Numerous clinical trials have been published to investigate the effect of Low Level infrared Light Therapy (LLLT) for diverse pathologies. Recent publications have elucidated how LLLT positively affects the mitochondrial function as well as documented promising results for Parkinson¿s and Alzheimer¿s diseases through in vitro and animal pre-clinical work. The goal of this project is to develop an implantable photo-stimulation system for controlled illumination of a specific region of the brain for the treatment of Parkinson¿s disease. Recent literature, as well as our own unpublished work on a drosophilia model, point to the possibility of treating altered mitochondrial function in Parkinson's disease by low level light therapy (LLLT). In preclinical tests we will first identify the optimal illumination conditions (wavelength, light dose, light intensity, dose repetition, and delivery route). This will be followed by the development of the technology to deliver light to a specific region of the brain in a controlled and safe way.

Abstract (Französisch)

Numerous clinical trials have been published to investigate the effect of Low Level infrared Light Therapy (LLLT) for diverse pathologies. Recent publications have elucidated how LLLT positively affects the mitochondrial function as well as documented promising results for Parkinson¿s and Alzheimer¿s diseases through in vitro and animal pre-clinical work. The goal of this project is to develop an implantable photo-stimulation system for controlled illumination of a specific region of the brain for the treatment of Parkinson¿s disease. Recent literature, as well as our own unpublished work on a drosophilia model, point to the possibility of treating altered mitochondrial function in Parkinson's disease by low level light therapy (LLLT). In preclinical tests we will first identify the optimal illumination conditions (wavelength, light dose, light intensity, dose repetition, and delivery route). This will be followed by the development of the technology to deliver light to a specific region of the brain in a controlled and safe way.