Assessment of RNA as a drug target - A systems approach to detection of RNA/drug interactions

• Research unit: INNOSUISSE
• Project number: 13924.1;7 PFLS-LS

Short description (English)

Assessment of RNA as a drug target - A systems approach to detection of RNA/drug interactions

Short description (French)

Assessment of RNA as a drug target - A systems approach to detection of RNA/drug interactions

Abstract (English)

The recent discovery of gene regulation by RNA secondary structure modification induced by natural ligand binding, termed the riboswitch, has given rise to a promising opportunity for new drug development using RNA as a target. A reliable method to characterise RNA/ligand interactions at a whole organism level would greatly facilitate this process but has yet to be developed. The proposed project is a feasibility study aiming to establish a novel universal method for RNA drug discovery by mapping and characterising RNA secondary structure modifications induced by RNA ligand interactions.

Abstract (French)

The recent discovery of gene regulation by RNA secondary structure modification induced by natural ligand binding, termed the riboswitch, has given rise to a promising opportunity for new drug development using RNA as a target. A reliable method to characterise RNA/ligand interactions at a whole organism level would greatly facilitate this process but has yet to be developed. The proposed project is a feasibility study aiming to establish a novel universal method for RNA drug discovery by mapping and characterising RNA secondary structure modifications induced by RNA ligand interactions.