Generation of a genetically characterized and improved CHO cell-based GMP production platform

• Unité de recherche: INNOSUISSE
• Numéro de projet: 13939.1;8 PFLS-LS
• Titre du projet anglais: Generation of a genetically characterized and improved CHO cell-based GMP production platform

Description succincte (Anglais)

Generation of a genetically characterized and improved CHO cell-based GMP production platform

Description succincte (Français)

Generation of a genetically characterized and improved CHO cell-based GMP production platform

Résumé des résultats (Abstract) (Anglais)

We propose to devise a CHO cell-based platform with a fully sequenced annotated genome, and to engineer it to facilitate the identification of new protein therapeutics, to decrease production costs and to improve the quality and safety of therapeutic proteins. Our scientific aims are: i) to complete the sequencing and annotate the CHO cell genome, ii) to develop a more efficient gene transfer process for improved therapeutic protein expression based on the genome sequence, and iii) to establish a process to characterize the genome of therapeutic-producing CHO cell clones, to provide better characterized therapeutic proteins and to facilitate regulatory approval.

Résumé des résultats (Abstract) (Français)

We propose to devise a CHO cell-based platform with a fully sequenced annotated genome, and to engineer it to facilitate the identification of new protein therapeutics, to decrease production costs and to improve the quality and safety of therapeutic proteins. Our scientific aims are: i) to complete the sequencing and annotate the CHO cell genome, ii) to develop a more efficient gene transfer process for improved therapeutic protein expression based on the genome sequence, and iii) to establish a process to characterize the genome of therapeutic-producing CHO cell clones, to provide better characterized therapeutic proteins and to facilitate regulatory approval.