Screening and optimization of fusion inhibitors of Respiratory Syncytial Virus

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12868.1;9 PFLS-LS

Project title

Screening and optimization of fusion inhibitors of Respiratory Syncytial Virus

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Short description (English)	Screening and optimization of fusion inhibitors of Respiratory Syncytial Virus
Abstract (English)	Respiratory syncytial virus infections are one of the leading causes of mortality in infants worldwide and cause a significant hospitalization burden both in the US and in Europe. There is currently only one treatment available, a prophylactic antibody (Synagis/Palivizumab) that is administered only to at risk premature infants because of its highly prohibitive cost. This project aims at screening pre-fractionated melusine venoms and rationally drug designed stapled peptides to identify molecules that inhibit virus entry into host cells.

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Text

Short description
(English)

Screening and optimization of fusion inhibitors of Respiratory Syncytial Virus

Abstract
(English)

Respiratory syncytial virus infections are one of the leading causes of mortality in infants worldwide and cause a significant hospitalization burden both in the US and in Europe. There is currently only one treatment available, a prophylactic antibody (Synagis/Palivizumab) that is administered only to at risk premature infants because of its highly prohibitive cost. This project aims at screening pre-fractionated melusine venoms and rationally drug designed stapled peptides to identify molecules that inhibit virus entry into host cells.