CAMEO- Characterization and optimization of selective and safe Modulators of the innate immune system for treatment of cancer and other diseases: a combined modelling/experimental study

• Unité de recherche: INNOSUISSE
• Numéro de projet: 13240.1;10 PFLS-LS
• Titre du projet anglais: CAMEO- ChAracterization and optimization of selective and safe Modulators of the innate immune system for treatment of cancer and other disEases: a combined mOdelling/experimental study

Description succincte (Anglais)

CAMEO- ChAracterization and optimization of selective and safe Modulators of the innate immune system for treatment of cancer and other disEases: a combined mOdelling/experimental study

Description succincte (Français)

CAMEO- Characterization and optimization of selective and safe Modulators of the innate immune system for treatment of cancer and other diseases: a combined modelling/experimental study

Résumé des résultats (Abstract) (Anglais)

The aim of this project is the characterization and optimization of Toll-like receptor 7 modulators¿ structure. Computational modeling, in synergy with cellular and molecular biology will provide detailed molecular information about their self-assembly properties, their interaction with the receptors and off-target problems. This knowledge will accelerate and focus the drugs optimization process leading to the GLP IND -enabling studies for entering subsequent clinical phases

Résumé des résultats (Abstract) (Français)

The aim of this project is the characterization and optimization of Toll-like receptor 7 modulators¿ structure. Computational modeling, in synergy with cellular and molecular biology will provide detailed molecular information about their self-assembly properties, their interaction with the receptors and off-target problems. This knowledge will accelerate and focus the drugs optimization process leading to the GLP IND -enabling studies for entering subsequent clinical phases