Abstract
(Englisch)
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The central nervous system (CNS) is a very complicated system with hundreds of different active molecules involved in
numerous processes in different anatomical and functional parts of the brain. The time course of synaptic currents is one
of the main factors determining how a single neuron integrates information coming from different inputs. Establishing the
temporal and concentration profiles of neurotransmitters during synaptic release is an essential step to monitor interneuronal
communications in the central nervous system in normal or pathological conditions. We propose to develop a
new in vitro assay that will allow us, by measuring the levels of neurotransmitters released from human neural networks
within a 3D neural model developed and produced by Neurix (MiniBrain), to assess the beneficial or deleterious effects of
new therapeutically compounds or chemicals found in our food and our environment. The profiling of neurotransmitters
released from human neural tissues will thus represent a more predictive and cost effective tool that will be integrated into
pharmaceutical and chemical industry platforms for early safety and neurotoxicology assays. The aim of this project is to
deliver a functional in vitro assay for neurotoxicity assessment which will be commercialized by Neurix.
|
Abstract
(Französisch)
|
The central nervous system (CNS) is a very complicated system with hundreds of different active molecules involved in
numerous processes in different anatomical and functional parts of the brain. The time course of synaptic currents is one
of the main factors determining how a single neuron integrates information coming from different inputs. Establishing the
temporal and concentration profiles of neurotransmitters during synaptic release is an essential step to monitor interneuronal
communications in the central nervous system in normal or pathological conditions. We propose to develop a
new in vitro assay that will allow us, by measuring the levels of neurotransmitters released from human neural networks
within a 3D neural model developed and produced by Neurix (MiniBrain), to assess the beneficial or deleterious effects of
new therapeutically compounds or chemicals found in our food and our environment. The profiling of neurotransmitters
released from human neural tissues will thus represent a more predictive and cost effective tool that will be integrated into
pharmaceutical and chemical industry platforms for early safety and neurotoxicology assays. The aim of this project is to
deliver a functional in vitro assay for neurotoxicity assessment which will be commercialized by Neurix.
|
