Design and Development of specific dual binding therapeutic antibodies by Retrocyte Display® technology and protein structure information.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 12972.1;6 PFLS-LS
• Titre du projet anglais: Design and Development of specific dual binding therapeutic antibodies by Retrocyte Display® technology and protein structure information.

Description succincte (Allemand)

Design and Production of Dual Binding therapeutic Antibodies by Guided selection through the Retrocyte Display® technology and protein structure information.

Description succincte (Anglais)

Design and Development of specific dual binding therapeutic antibodies by Retrocyte Display® technology and protein structure information.

Résumé des résultats (Abstract) (Allemand)

This proposal aims at combining 4-Antibody¿s proprietary Retrocyte Display® technology for the discovery of fully human antibodies with the expert know-how of the FHNW-ICB laboratory in the structure-function analysis of biologics and protein-protein complexes for the development of optimized therapeutic antibodies that specifically target two or more different disease targets within a single monoclonal antibody. This new drug format could significantly improve the potency of conventional antibody drugs, which are traditionally only monospecific.

Résumé des résultats (Abstract) (Anglais)

This proposal aims at combining 4-Antibody¿s proprietary Retrocyte Display® technology for the discovery of fully human antibodies with the expert know-how of the FHNW-ICB laboratory in the structure-function analysis of biologics and protein-protein complexes for the development of optimized therapeutic antibodies that specifically target two or more different disease targets within a single monoclonal antibody. This new drug format could significantly improve the potency of conventional antibody drugs, which are traditionally only monospecific.