Design and Development of specific dual binding therapeutic antibodies by Retrocyte Display® technology and protein structure information.

• Research unit: INNOSUISSE
• Project number: 12972.1;6 PFLS-LS

Short description (German)

Design and Production of Dual Binding therapeutic Antibodies by Guided selection through the Retrocyte Display® technology and protein structure information.

Short description (English)

Design and Development of specific dual binding therapeutic antibodies by Retrocyte Display® technology and protein structure information.

Abstract (German)

This proposal aims at combining 4-Antibody¿s proprietary Retrocyte Display® technology for the discovery of fully human antibodies with the expert know-how of the FHNW-ICB laboratory in the structure-function analysis of biologics and protein-protein complexes for the development of optimized therapeutic antibodies that specifically target two or more different disease targets within a single monoclonal antibody. This new drug format could significantly improve the potency of conventional antibody drugs, which are traditionally only monospecific.

Abstract (English)

This proposal aims at combining 4-Antibody¿s proprietary Retrocyte Display® technology for the discovery of fully human antibodies with the expert know-how of the FHNW-ICB laboratory in the structure-function analysis of biologics and protein-protein complexes for the development of optimized therapeutic antibodies that specifically target two or more different disease targets within a single monoclonal antibody. This new drug format could significantly improve the potency of conventional antibody drugs, which are traditionally only monospecific.