Design and Production of Dual Binding therapeutic Antibodies by Guided selection through the Retrocyte Display® technology and protein structure information.

• Forschungsstelle: INNOSUISSE
• Projektnummer: 12972.1;6 PFLS-LS
• Projekttitel Englisch: Design and Development of specific dual binding therapeutic antibodies by Retrocyte Display® technology and protein structure information.

Kurzbeschreibung (Deutsch)

Design and Production of Dual Binding therapeutic Antibodies by Guided selection through the Retrocyte Display® technology and protein structure information.

Kurzbeschreibung (Englisch)

Design and Development of specific dual binding therapeutic antibodies by Retrocyte Display® technology and protein structure information.

Abstract (Deutsch)

This proposal aims at combining 4-Antibody¿s proprietary Retrocyte Display® technology for the discovery of fully human antibodies with the expert know-how of the FHNW-ICB laboratory in the structure-function analysis of biologics and protein-protein complexes for the development of optimized therapeutic antibodies that specifically target two or more different disease targets within a single monoclonal antibody. This new drug format could significantly improve the potency of conventional antibody drugs, which are traditionally only monospecific.

Abstract (Englisch)

This proposal aims at combining 4-Antibody¿s proprietary Retrocyte Display® technology for the discovery of fully human antibodies with the expert know-how of the FHNW-ICB laboratory in the structure-function analysis of biologics and protein-protein complexes for the development of optimized therapeutic antibodies that specifically target two or more different disease targets within a single monoclonal antibody. This new drug format could significantly improve the potency of conventional antibody drugs, which are traditionally only monospecific.