Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

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Project number

12356.1;8 PFLS-LS

Project title

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

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Short description (English)	Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria
Abstract (English)	We have recently discovered new peptidomimetic antibiotics targeting a protein (LptD) essential for outer membrane biogenesis in Pseudomonas spp. The peptidomimetics protect against P. aeruginosa in a mouse infection model, and a clinical lead has entered a phase I clinical trial. The goals of this project are to extend the spectrum of activity of these compounds, and to develop new antibiotics targeting other Gram-negative pathogens. The work should lead to an important new class of antibiotics to combat drug-resistant Gram-negative 'super-bugs'.

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Short description
(English)

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

Abstract
(English)

We have recently discovered new peptidomimetic antibiotics targeting a protein (LptD) essential for outer membrane biogenesis in Pseudomonas spp. The peptidomimetics protect against P. aeruginosa in a mouse infection model, and a clinical lead has entered a phase I clinical trial. The goals of this project are to extend the spectrum of activity of these compounds, and to develop new antibiotics targeting other Gram-negative pathogens. The work should lead to an important new class of antibiotics to combat drug-resistant Gram-negative 'super-bugs'.