Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

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Forschungsstelle

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Projektnummer

12356.1;8 PFLS-LS

Projekttitel

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

Projekttitel Englisch

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

Texte zu diesem Projekt

	Deutsch	Französisch	Italienisch	Englisch
Kurzbeschreibung	-	-	-
Abstract	-	-	-

Erfasste Texte

Kategorie	Text
Kurzbeschreibung (Englisch)	Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria
Abstract (Englisch)	We have recently discovered new peptidomimetic antibiotics targeting a protein (LptD) essential for outer membrane biogenesis in Pseudomonas spp. The peptidomimetics protect against P. aeruginosa in a mouse infection model, and a clinical lead has entered a phase I clinical trial. The goals of this project are to extend the spectrum of activity of these compounds, and to develop new antibiotics targeting other Gram-negative pathogens. The work should lead to an important new class of antibiotics to combat drug-resistant Gram-negative 'super-bugs'.

Kategorie

Text

Kurzbeschreibung
(Englisch)

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

Abstract
(Englisch)

We have recently discovered new peptidomimetic antibiotics targeting a protein (LptD) essential for outer membrane biogenesis in Pseudomonas spp. The peptidomimetics protect against P. aeruginosa in a mouse infection model, and a clinical lead has entered a phase I clinical trial. The goals of this project are to extend the spectrum of activity of these compounds, and to develop new antibiotics targeting other Gram-negative pathogens. The work should lead to an important new class of antibiotics to combat drug-resistant Gram-negative 'super-bugs'.