Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

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Identifiant

Unité de recherche

INNOSUISSE

Numéro de projet

12356.1;8 PFLS-LS

Titre du projet

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

Titre du projet anglais

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

Textes relatifs à ce projet

	Allemand	Français	Italien	Anglais
Description succincte	-	-	-
Résumé des résultats (Abstract)	-	-	-

Textes saisis

Catégorie	Texte
Description succincte (Anglais)	Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria
Résumé des résultats (Abstract) (Anglais)	We have recently discovered new peptidomimetic antibiotics targeting a protein (LptD) essential for outer membrane biogenesis in Pseudomonas spp. The peptidomimetics protect against P. aeruginosa in a mouse infection model, and a clinical lead has entered a phase I clinical trial. The goals of this project are to extend the spectrum of activity of these compounds, and to develop new antibiotics targeting other Gram-negative pathogens. The work should lead to an important new class of antibiotics to combat drug-resistant Gram-negative 'super-bugs'.

Catégorie

Texte

Description succincte
(Anglais)

Peptidomimetic Antibiotics Targeting Outer Membrane Biogenesis in Gram-Negative Bacteria

Résumé des résultats (Abstract)
(Anglais)

We have recently discovered new peptidomimetic antibiotics targeting a protein (LptD) essential for outer membrane biogenesis in Pseudomonas spp. The peptidomimetics protect against P. aeruginosa in a mouse infection model, and a clinical lead has entered a phase I clinical trial. The goals of this project are to extend the spectrum of activity of these compounds, and to develop new antibiotics targeting other Gram-negative pathogens. The work should lead to an important new class of antibiotics to combat drug-resistant Gram-negative 'super-bugs'.