Entwicklung Syndrom basierter Überwachungsstrategien neuroinfektiöser Krankheiten bei Tieren

• Forschungsstelle: BLV
• Projektnummer: 1.12.13
• Projekttitel Englisch: Development of syndromic surveillance strategies for neuroinfectious diseases in animals

Schlüsselwörter (Deutsch)

Aufkommende Krankheiten, Infektionskrankheiten, Syndrom basierte Überwachung, Risikoabschätzung, Nutztiere, Neuropathologie, Wiederkäuer

Schlüsselwörter (Englisch)

Emerging diseases, infectious diseases, syndromic surveillance, risk assessment, zoonoses, livestock, neuropathology , ruminants

Kurzbeschreibung (Deutsch)

Neu- und wiederaufkommende Infektionserkrankungen bei Tieren stellen eine latente Gefahr für die Tiergesundheit und den Verbraucher dar. Daher ist es von grosser Wichtigkeit, schnellstmöglich Ausbrüche zu erkennen und wirksame Bekämpfungsmassnahmen zu treffen. Syndrom basierte Überwachung bietet die Möglichkeit, Veränderungen in der Prävalenz von Erkrankungen in einer Population im Sinne eines Frühwarnsystems zu erkennen. In dieser Projektskizze schlagen wir vor, die aktuelle Situation in der Überwachung und Diagnostik von neuroinfektiösen Erkrankungen zu analysieren, vorhandene Lücken zu identifizieren und die Machbarkeit  einer Syndrom basierten Überwachung dieser Erkrankungen in einer Pilot-Studie zu evaluieren. Anhand der Resultate werden wir Vorschläge für eine wirksame und kosteneffiziente Überwachung neuroinfektiöser Erkrankungen in der Schweiz erarbeiten.

Kurzbeschreibung (Englisch)

Emerging and re-emerging infectious diseases present a latent risk to animal health and consumers. Therefore, the rapid identification of outbreaks is of utmost importance to implement potent disease control measures. Syndromic surveillance allows to detect changes in the prevalence of diseases in terms of an early-warning system. In the present project we propose to analyse the current situation in the surveillance and diagnostic of neuroinfectious diseases, to identify gaps in that and to evaluate the feasibility of a syndromic surveillance of these diseases in a pilot-study. Based on the results, we will develop a proposal for an effective and cost-efficient surveillance of neuroinfectious diseases in Switzerland.

Projektziele (Englisch)

The proposed project is rather a conceptual than a fundamental research project. It aims at identification of the maximum performance of surveillance systems for neuroinfectious diseases by optimizing the use of existing data sources, at identification of gaps and at suggestion of follow-up projects to fill these gaps.

The objectives of the proposed project are…

… to investigate the total sensitivity of the existing MOSS activities for neuroinfectious diseases by analysing the current situation of surveillance and diagnosis of neuroinfectious diseases of livestock in the clinics, pathology institutes, national health schemes and existing surveillance programs.

…to conduct a pilot study by examination of brain samples of fallen cattle and those that were autopsied in the pathology institutes using histopathological examination and subsequent etiological clarification to generate baseline data on syndrome (disease) prevalence and the correlation of clinical symptoms/syndromes with neuropathological/laboratory diagnostic data.

…to identify gaps

- in disease specific diagnostic techniques,

- in the interconnection with specialist laboratories for the diagnosis of specific diseases,

- in knowledge about the (lack of) correlation between clinical symptoms/syndromes on the one hand and neuropathological and laboratory diagnostic findings on the other hand,

- in MOSS activities.

… to assess the feasibility and cost-effectiveness of syndromic surveillance for neuroinfectious diseases by estimating sensitivity and cost for current and future surveillance systems components such as clinical examination, anamnestic information available on perished animals, scanning of brain samples by histopathology and training programs for livestock owners.

…to preferentially evaluate syndromic surveillance strategies to monitor neuroinfectious diseases in horses, with special emphasis on the early detection of West Nile Fever.

…to suggest follow-up projects to fill the most relevant gaps preventing us from applying cost-effective surveillance of neuroinfectious diseases.

Publikationen / Ergebnisse (Englisch)

Walland, J. Project presentation. Workshop on early-warning systems in Switzerland, March 4th 2013, Bern

Walland, J.; Lauper, J.; Frey, J.; Imhof, R.; Stephan, R.;  Seuberlich, T.; Oevermann, A. Listeria monocytogenes infection in ruminants: Is there a link to the environment, food and human health? A review. Schweiz Arch Tierheilkd. 2015 Jun;157(6):319-28. Review and Disseration Dr. med. vet, University of Berne.

Seuberlich, T. Surveillance of listeric encephalitis in ruminants in Switzerland. Listeria Mini-Symposium. University of Berne. 14. November 2014.

Truchet, L. Scanning surveillance of neuroinfectious diseases in cattle livestock. Swiss Virology Meeting. Thun 2./3. February 2016.

Truchet, L.; Walland, J.; Wüthrich, D.; Posthaus, H.; Bruggmann, R.; Schüpbach, G.; Oevermann, A.; Seuberlich, T. Active scanning surveillance of neuroinfectious diseases in cattle livestock in Switzerland.

Zugehörige Dokumente

• 1.12.13 Seuberlich DB/MjB [PDF] 148 kB
• 1.12.13 Seuberlich überarbeitetes DB [PDF] 151 kB

URL-Adressen (Deutsch)

1.12.13 Seuberlich Entwicklung Syndrom-basierter Überwachungsstrategien neuroinfektiöser Krankheite…