Development and production of novel sustained release dosage forms for active vitamin D3 to prevent milk fever in cows.

• Research unit: INNOSUISSE
• Project number: 11750.1;8 PFLS-LS

Short description (German)

Entwicklung und Herstellung von neuartigen Retard-Darreichungsformen mit aktivem Vitamin D3 zur Milchfieberprävention bei Kühen.

Short description (English)

Development and production of novel sustained release dosage forms for active vitamin D3 to prevent milk fever in cows.

Abstract (German)

Milk fever (periparturient hypocalcaemia) in cows is still responsible for considerable economic loss. Solbovine, containing the active vitamin D3, is a new approach in prevention of the disorder. In this project, an optimal sustained drug delivery system for single oral application in ruminants will be developed ensuring a drug release for at least 48 h and increased blood level for 4 days. The testing will be carried out in vitro and in vivo. Data simulation will be part of the evaluation.