Advanced 3D cell biology - From cancer biopsies to physiologically relevant in vitro models

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INNOSUISSE

Numéro de projet

11941.1;7 PFLS-LS

Titre du projet

Advanced 3D cell biology - From cancer biopsies to physiologically relevant in vitro models

Titre du projet anglais

Advanced 3D cell biology - From cancer biopsies to physiologically relevant in vitro models

Textes relatifs à ce projet

	Allemand	Français	Italien	Anglais
Description succincte	-	-	-
Résumé des résultats (Abstract)	-	-	-

Textes saisis

Catégorie	Texte
Description succincte (Anglais)	Advanced 3D cell biology - From cancer biopsies to physiologically relevant in vitro models
Résumé des résultats (Abstract) (Anglais)	The high attrition rate of late stage anti-cancer drug candidates has led drug developers to reassess in vitro tumor models used to select and validate drug targets and subsequent lead molecules. 3D cell cultures provide physiologically more relevant cells than the conventional Petri dish approach, especially for cancer cells. Hence, the aim of this feasibility study is to demonstrate the concept of a new tool to isolate prostate tumor cells, based on membrane protein specific aptamers, in an in-vivo like environment based on the existing industrial partners 3D cell culture technology.

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Texte

Description succincte
(Anglais)

Advanced 3D cell biology - From cancer biopsies to physiologically relevant in vitro models

Résumé des résultats (Abstract)
(Anglais)

The high attrition rate of late stage anti-cancer drug candidates has led drug developers to reassess in vitro tumor models used to select and validate drug targets and subsequent lead molecules. 3D cell cultures provide physiologically more relevant cells than the conventional Petri dish approach, especially for cancer cells. Hence, the aim of this feasibility study is to demonstrate the concept of a new tool to isolate prostate tumor cells, based on membrane protein specific aptamers, in an in-vivo like environment based on the existing industrial partners 3D cell culture technology.