Novel therapeutic strategies for allergic diseases

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Research unit

INNOSUISSE

Project number

12176.1;10 PFLS-LS

Project title

Novel therapeutic strategies for allergic diseases

Texts for this project

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Short description	-	-	-
Abstract	-	-	-

Inserted texts

Category	Text
Short description (English)	Novel therapeutic strategies for allergic diseases
Abstract (English)	In the scope of this project we seek to develop both a bispecific DARPin molecule and an anti-IgE antibody each targeting two regulatory receptors on the surface of basophils and mast cells. Both drug candidates will be evaluated for their capacity to negatively regulate IgE-induced basophil and mast cell activation and to inhibit IgE synthesis by B cells. Both drug candidates represent an innovative approach different from existing treatment strategies. Since proof of concept has already been reached in a previous collaboration, this grant application serves to create the scientific basis to decide which of the two strategies may be incorporated into the pipeline of the industrial partner.

Category

Text

Short description
(English)

Novel therapeutic strategies for allergic diseases

Abstract
(English)

In the scope of this project we seek to develop both a bispecific DARPin molecule and an anti-IgE antibody each targeting two regulatory receptors on the surface of basophils and mast cells. Both drug candidates will be evaluated for their capacity to negatively regulate IgE-induced basophil and mast cell activation and to inhibit IgE synthesis by B cells. Both drug candidates represent an innovative approach different from existing treatment strategies. Since proof of concept has already been reached in a previous collaboration, this grant application serves to create the scientific basis to decide which of the two strategies may be incorporated into the pipeline of the industrial partner.