Design, development and process use of a novel production scale disposable bioreactor system for therapeutic recombinant protein synthesis by mammalian cells.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 10924.1;11 PFLS-LS
• Titre du projet anglais: Design, development and process use of a novel production scale disposable bioreactor system for therapeutic recombinant protein synthesis by mammalian cells.

Description succincte (Anglais)

Design, development and process use of a novel production scale disposable bioreactor system for therapeutic recombinant protein synthesis by mammalian cells.

Description succincte (Français)

Design, development and process use of a novel production scale disposable bioreactor system for therapeutic recombinant protein synthesis by mammalian cells.

Résumé des résultats (Abstract) (Français)

Previous research funding by KTI provided insight for a novel single-use 200-L bioreactor system (OrbShake®200) leading to its marketing by Kühner AG. A prototype 3¿500-L bioreactor (working volume of 2¿500 L) is being designed by Kühner AG with the intention of expanding the ongoing research in large-scale orbital shaking with the ultimate goal of its commercialization. The main issues are the engineering aspects of large-scale shaken reactors and the cell biological constraints on fluid handling, oxygen supply, and carbon dioxide removal.