Development of a biodegradable drug delivery system on metal implants supporting bone regeneration and enhancing fixation.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 11098.1;11 PFLS-LS
• Titre du projet anglais: Development of a biodegradable drug delivery system on metal implants supporting bone regeneration and enhancing fixation.

Description succincte (Allemand)

Development of a biodegradable drug delivery system on metal implants supporting bone regeneration and enhancing fixation.

Description succincte (Anglais)

Development of a biodegradable drug delivery system on metal implants supporting bone regeneration and enhancing fixation.

Résumé des résultats (Abstract) (Allemand)

This project is to develop an innovative orthopaedic implant composed of a metal bone screw and a biodegradable drug delivery system to locally administer Bisphosphonates. Implant surfaces will be modified with selected poly-lactides offering a variety of degradation features, making them ideal candidates for hosting and releasing pharmaceutical agents. The bio-coating will be analyzed by means of physical, chemical and pharmaceutical means. Finally, safety and efficacy of the bioactive coating will be demonstrated in a preclinical investigation.